Posted by roversreturn on February 20, 2012, at 20:28:53
In reply to Re: ketamine can cause psychosis...does it??, posted by Novelagent on February 20, 2012, at 16:33:17
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> http://www.ketamine.com/schizohypoth.html
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>
> > > If you are predisposed (and never rule out your ancestry has a secret) you could be at risk for a bad trip which could trigger schizophrenia.
> > >
> > > Since I'm not aware of any research that has been done on trying to figure out if the kind of trip counselling places like Johns Hopkins uses for their MAPS program compensates for someone at risk for a bad trip, I'm a bit weary of the enthusiasm for this stuff. On the other hand, it would be nice to know if tripping is something that trip counselling can make safe even for someone with psychosis (stabalized on an antipsychotic).
> > >
> > > Unfortunately, I've written off the prospects of tripping in this lifetime so far.
> > >
> >
> > It may cause temporary symptoms in the first couple of hours, but i have never heard of this, and i am unaware of the mechanism by which its proposed - if you could cite a source for your argument I would be grateful.
> >
> > Many thanks
> >
> > Rover
>
>Ok great, you may be right that this could be a no no for people suffering from schiz, but i would argue they may get better when the drug leaves their system (as in depression).
The article implies that ketamine's temporary activity on glutamte in brain during the time the drug is taken means that even 'normal' people have temporary symptoms of schizophrenia, this can be attentuated by lamotrigine apparently, once the two hours or so has passed one would expect to feel 'normal'. This is when the antidepressant effect appears to kick in.
"The psychomimetic effects of ketamine are transitional, reversible and influenced by time, dose and administration conditions". Therefore one would not expect ketamine to attribute to onset of schizophrenia, in the way that say, cannabis had been hypothesised.
Thanks
Rover
poster:roversreturn
thread:1010025
URL: http://www.dr-bob.org/babble/20120212/msgs/1011042.html