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Re: Cariprazine - Great news, hopefully. » ed_uk2010

Posted by SLS on February 10, 2012, at 7:39:24

In reply to Re: Cariprazine - Great news, hopefully. » SLS, posted by ed_uk2010 on February 10, 2012, at 6:33:14

> >Anyway, I am excited about this drug.
>
> There is information on the Gedeon Richter website. Fortunately, you can click to read in English. My Hungarian is a little rusty. Anyway, you can read about the trials here...
>
> http://www.richter.hu/EN/Pages/Search.aspx?stype=F&query=cariprazine
>
> It seems effective in bipolar mania and probably schizophrenia. They also have some preliminary data in MDD and bipolar depression.


Thanks, Ed.

I reviewed the abstracts to be found on Medline/Pubmed relating to cariprazine. Rats and mice have unanimously endorsed its approval for human use.

But seriously...

The findings of this study are quite salient and worth a look:

http://www.ncbi.nlm.nih.gov/pubmed/21767587

Perhaps cariprazine will be less liable to produce the undesirable cognitive side effects that Abilify (aripiprazole) does in some people, especially at higher dosages. This is probably the result of cariprazine having a greater D3/D2 ratio of binding affinities when compared to Abilify. Perhaps this would increase treatment compliance with cariprazine when treating psychotic disorders and make the drug more tolerable for people using it for depression.

It seems to me that people who are treating MDD with Abilify are more likely to be intolerant of dosages above 2.5 mg/day when compared to people being treated for psychotic disorders. Anxiety and cognitive blunting appear to limit dosage increases. I don't see that this is so much of an issue with people treating bipolar depression. I could be wrong.

I learned recently that 5-HT1a agonism mitigates EPS. Both Abilify and cariprazine have this property. So do Geodon, Latuda, and Saphris. I don't know if akathisia was taken into consideration, though. Abilify does seem to produce akathisia more often than the other atypical antipsychotics.

http://www.ncbi.nlm.nih.gov/pubmed/20571976

Sorry to ramble.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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