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Re: Adding Parnate and prazosin. » ed_uk2010

Posted by SLS on February 5, 2012, at 21:53:01

In reply to Re: Adding Parnate and prazosin. » SLS, posted by ed_uk2010 on February 5, 2012, at 17:57:45

> >I think partial agonism at both receptors is important to produce an antidepressant effect.
>
> What is the role of D3 receptors in depression?

D3 receptors occur in limbic structures such as the nucleus accumbens, a region that mediates reward, pleasure, and drive. Dysfunction here is thought to be responsible for anhedonia.

"and a D2/D3 dopamine receptor agonist exhibits antidepressant-like effects in numerous depression models including learned helplessness paradigm and chronic mild stress model [104]. Moreover, it has been reported that stimulation of D2/3 dopamine receptors, but not of the D4 dopamine receptor, exhibits an antidepressant-like effect in the forced swimming test [12]"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475798/

DBS in the nucleus accumbens reduces depression.

"We demonstrate antidepressant and antianhedonic effects of DBS to NAcc in patients suffering from TRD."

http://www.ncbi.nlm.nih.gov/pubmed/19914605

> Also, does Fanapt have a role in mood disorders? I'm not very familiar with this drug at all.

I tried Fanapt (iloperidone), but I didn't like it for some reason. I don't remember why. Looking at its binding profile, I see that Fanapt acts like prazosin at the NE alpha-1 receptor. Interesting.

http://www.ncbi.nlm.nih.gov/pubmed/11750183


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poster:SLS thread:1005781
URL: http://www.dr-bob.org/babble/20120202/msgs/1009425.html