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Re: Motivation vs. Anhedonia » alchemy

Posted by bleauberry on January 29, 2012, at 8:09:08

In reply to Re: Motivation vs. Anhedonia » bleauberry, posted by alchemy on January 28, 2012, at 10:07:20

> Interesting. Low doses can be better; serotonin + norepiniphrine; and wellbutrin isn't always the cure-all. I have actually never tried marijuana, but I thought that it induced more of a lack of motivation?

Let me clarify. I am not endorsing cannabis. Just sayin, for the symptoms in question, it is an option and in certain States is a legal option. Now, cannabis species vary a lot, the same as SSRI species vary a lot. Lexapro does not feel like Prozac, right? For motivational symptoms, specific species from the Sativa class are the ones. Species from the Indica class will certainly land you on the couch like a potato and you wouldn't care if you had motivation or not. That's not the right kind.
>
> Ya, I don't have much hopes for Strattera & it actually kind of scares me that it could make me worse. I started out on 1/4 of 10mg - 10mg is the normal starting dose in the pack. Just got to 10mg. It's definitely not helping - but I don't think it's making it worse (so far anyway). I read someone's experience with it that struck me. She had a very positive experience with it for her adhd and could finally "hear the passage of time". What? For me the passage of time is screaming and annoying.
>
> I ordered Trivastal from United Pharmacies and it didn't help, although there were only 10 pills. I'm hoping that they were fake and that I might still have success on Requip or Mirapex.
>
> I guess the SNRIs are serotonin + norepinephrine. I've tried those too. I tried Pristiq a year or two ago and I started to have worse cyclothymia - more often & more intense. 2pm or 10am could come around and wham- mood plunge.

Well, the SNRIs really are not serotonin + norepinephrine. They do hit norepinephrine a tiny bit, just barely enough that from a marketing point of view they could say SNRI. Here are the ratios for SNRIs:

Cymbalta 9 parts serotonin to 1 part norepinephrine.
Effexor 30 parts serotonin to 1 part norepinephrine.
Savella 2 parts serotonin to 3 parts norepinephrine.

So the only true SNRI in that list is Savella. Another one is Clomipramine. The others are marketing gimmics.
>
> I am on 300mg of Wellbutrin. I've been on and off of it before. I think it helps a little. I did try and go up to 400mg once and I didn't like it.
>
> Thanks for responding and for the info.
>


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poster:bleauberry thread:1008490
URL: http://www.dr-bob.org/babble/20120120/msgs/1008716.html