Posted by tensor on January 15, 2012, at 8:27:02
In reply to does anyone know diffrence between Pro/Nuvigel?, posted by rjlockhart04-08 on January 15, 2012, at 0:00:26
> im on Nuvigel 150mg. Whats the diffrence between provigel?
From http://www.epharmacies.com/online-pharmacy-medicine-blog/should-you-switch-from-provigil-to-nuvigil/
"Dr. Ed Zimney, for one, doesnt seem to think Nuvigil is worth the higher price. He explains:
When a drug company has a successful product, they get very concerned when it gets close to the time for patent expiration because it means that cheap generic equivalents will soon appear. There are any number of strategies that companies use to protect their interests in this situation, and one of the most common is to take a look at the drugs chemistry to see if theres anything there to exploit. One possibility is to reformulate the product into something that lasts longer than the original, so youll see things like extended-release or controlled-release formulations being developed. Another typical strategy is to look at the drugs chemical forms, called isomers.
Without getting too deeply into it, many chemicals have two isomers and in many cases only one of them is actually active. So a common strategy is to see whether a new drug can be created that contains only the active isomer. Youve probably heard of Nexium (the purple pill), which is the active isomer of what was previously sold as Prilosec. There are many other examples.
So the people at Cephalon were starting to worry about their patent on Provigil because there were a number of lawsuits pending from generic drug manufacturers eager to get the rights to sell it. And it turns out that Provigil does have two isomers. In this particular case, they are both active, but one is eliminated from the body much more quickly than the other, so essentially the activity really comes from one isomer. Hence the development of Nuvigil, the longer-acting isomer formulation of Provigil."
Regards.
poster:tensor
thread:1007276
URL: http://www.dr-bob.org/babble/20120108/msgs/1007289.html