Re: Adding Parnate and prazosin. » Bob

Posted by SLS on January 4, 2012, at 23:39:33

In reply to Re: Adding Parnate and prazosin. » SLS, posted by Bob on January 4, 2012, at 14:50:31

> I'm still lost. Is causing NE alpha-1 receptors to downregulate a desired effect
Apparently, it is. It should reduce NE activity, thereby reducing anxiety.
> Logically it would seem to me that if you are blocking the receptors it would reduce the available NE to the brain?
Prazosin does not reduce the amount of norepinephrine neurotransmitter in the brain.
When NE attaches to a receptor, that receptor is stimulated to perform a function (either excitatory or inhibitory). Blocking this receptor using an antagonist or using an inverse agonist serves to prevent this function. Prazosin is an antagonist at excitatory NE alpha-1 receptors, thus reducing the number of receptors available for stimulation.
I hope this helps. Maybe I'm confusing things.

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

Thread

Adding Parnate and prazosin. SLS 12/29/11
...
Re: Adding Parnate and prazosin. Bob 1/4/12
Re: Adding Parnate and prazosin. » Bob SLS 1/4/12
Re: Adding Parnate and prazosin. » SLS sigismund 1/4/12
Re: Adding Parnate and prazosin. sigismund 1/4/12
Re: Adding Parnate and prazosin. » sigismund SLS 1/4/12
Re: Adding Parnate and prazosin. sigismund 1/4/12
Re: Adding Parnate and prazosin. » sigismund SLS 1/4/12
Re: Adding Parnate and prazosin. » SLS Bob 1/4/12
Re: Adding Parnate and prazosin. » SLS Bob 1/4/12
Re: Adding Parnate and prazosin. » SLS Phillipa 1/4/12
Re: Adding Parnate and prazosin. Phillipa 1/4/12
Re: Adding Parnate and prazosin. » Phillipa SLS 1/4/12
Re: Adding Parnate and prazosin. » Bob SLS 1/4/12
Re: Adding Parnate and prazosin. » SLS Bob 1/5/12
Re: Adding Parnate and prazosin. » SLS Bob 1/5/12
Re: Adding Parnate and prazosin. » Bob SLS 1/5/12
Re: Adding Parnate and prazosin. » Bob SLS 1/5/12
Re: Adding Parnate and prazosin. » SLS sigismund 1/5/12
Re: Adding Parnate and prazosin. sigismund 1/5/12
Re: Adding Parnate and prazosin. SLS 1/5/12
Re: Adding Parnate and prazosin. - Cingulate SLS 1/5/12
Re: Adding Parnate and prazosin. » sigismund SLS 1/5/12
Re: Adding Parnate and prazosin. » SLS g_g_g_unit 1/5/12
Re: Adding Parnate and prazosin. » g_g_g_unit SLS 1/5/12
Re: Adding Parnate and prazosin. » SLS sigismund 1/5/12
...
Re: Adding Parnate and prazosin + Topamax » Tomatheus SLS 7/13/12

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