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Re: lithium 5-ht1b + gsk-3b

Posted by SLS on December 26, 2011, at 11:19:48

In reply to Re: lithium 5-ht1b + gsk-3b, posted by Phillipa on December 26, 2011, at 9:44:20

> How does lithium control and provide relief from mania?


One mechanism proposed is the inhibition of protein kinase C (PKC) and a reduction in the activity of membrane-bound G-protein dopamine and glutamate receptors. Another involves the inhibition of dopamine receptor glycogen synthase kinase-3 (GSK-3) signalling. Note that these explain mania rather than depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1005569
URL: http://www.dr-bob.org/babble/20111226/msgs/1005589.html