Posted by SLS on November 17, 2011, at 7:12:32
In reply to NE reduction?, posted by Seige on November 17, 2011, at 3:16:06
Downregulation is not occurring in the absence of increased concentrations of NE in the synaptic cleft. Perhaps downregulation is compensating for overstimulation such that the net effect is to arrive at a new equilibrium that supports an increase in postsynaptic activation (personal theory).
You might want to read more on neuron function and how over-stimulation of postsynaptic receptors actually reduces the rate of action potentials. I believe this phenomenon is known as "accommodation". I use this as the basis for the way I conceptualize the way reuptake inhibitors might work.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1002855
URL: http://www.dr-bob.org/babble/20111110/msgs/1002861.html