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Seratonin Syndrome Effexor and Tramadol

Posted by IslandAngel on October 28, 2011, at 0:12:19

I feel like I am trying to keep my head above water, feel confused, weird, like I'm standing/sitting sideways, foggy, hot face. My head feels like a bobble head. It sounds funny but it is not. This is not a good feeling. I just got off the phone with my psychiatrist. I recently switched from Cymbalta to Effexor. Cymbalta made me cry all the time.

I have Spondylitis and I am having a major flare that affects my tendons (aka enthesopathy). Right leg, achilles tendon got so bad I have to wear an air cast/boot. My PCP prescribed Tramadol. Took 150 mg Tramadol last night and it seemed to work fine and put me right to sleep. Took Effexor this morning, I took 50mg Tramadol. The Tramadol didn't do much so took another this afternoon. OMG! Big mistake!!! I'm at work and the serotonin overload symptoms hit. I work at a hospital so I looked at the drug interaction checker. Big warning label! Husband got me to call my Psych doc. Psych doc confirmed I am experiencing Serotonin Syndrome. UGH! What an awful feeling. I want to share this story so anyone taking SSRI should be aware of this and do not take Tramadol!
Tramadol inhibits reuptake of serotonin and noradrenalin. It's a bummer because when I first took it at night I thought it worked so well without the feeling of a narcotic. Then, morning taking Effexor and Tramadol... big no no.

By the way, Effexor does not work for me. Disappointment. Will wean off of it and try something else. Effexor made OCD thoughts incredibly worse (intrusive thoughts, excessive rumination, picking face).
Appreciate your comments and input.

About me:
40 yr old female, Ankylosing Spondylitis, Fibromyalgia and inattentive ADD. Enbrel 25mg shots every 72 hours, Effexor, Adderall as needed, Gabapentin 2,300mg per day (divided doses).



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poster:IslandAngel thread:1001031
URL: http://www.dr-bob.org/babble/20111027/msgs/1001031.html