Posted by Chairman_MAO on October 7, 2011, at 6:57:19
In reply to can anyone give some success stories on parnate?, posted by rjlockhart04-08 on September 30, 2011, at 20:23:22
It is a completely different experience than the SSRIs.
It made me more outgoing and helped with social phobia, increased sex drive, caused a lot of insomnia, and of course helped with depression. Insomnia was the worst side effect for me--and the changes in effect of it throughout the day. The MAOI effect is constant, but the drug itself also has psychostimulant properties that don't last very long.
"Gentleness doesn't suit everyone. Moclobemide isn't much good at lifting deep melancholy. Tranylcypromine (Parnate), on the other hand, is one of the older and non-selective MAOIs - and is often none the worse for it. Structurally related to amphetamine, tranylcypromine is generally the most stimulating, dopaminergic and relatively fast-acting of the MAOIs. Some doctors are uncomfortable with its properties. This isn't just because of the dietary restrictions its use demands. In adequate doses, tranylcypromine tends to induce a mild euphoria even in "normal" subjects. Tranylcypromine use increases trace amines, modulates phospholipid metabolism and up-regulates GABA(B) receptors. In fact, its nicest effects, as for all of the compounds cited here, will vary in nature and extent from person to person. To some extent, optimal dosage and long-term drug-regimen of choice can be discovered only by (cautious) empirical self-investigation."
(see www.biopsychiatry.com)
poster:Chairman_MAO
thread:998390
URL: http://www.dr-bob.org/babble/20111006/msgs/998999.html