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Re: Phenobarbital as a benzo detox » Chairman_MAO

Posted by SLS on October 6, 2011, at 5:31:47

In reply to Re: Phenobarbital as a benzo detox » SLS, posted by Chairman_MAO on October 5, 2011, at 23:09:10

> If I had to pick one off the top of my head, this layman's choice would be topiramate (many mechanisms of action). Oh, and throw in memantine on top of that also for good measure (each drug acts as a blocker of a different subtype of glutamate receptor).
>
> Tegretol certainly has been used in the past. Complex topic, and I'm off to bed.
>
> What do you think?

Your proposed cocktail is intriguing. I would not have thought to add memantine to the list. I think there must be antiglutamatergic and anti-kindling properties combined. I guess pro-GABAergic drugs would help with anxiety.

I know that topiramate keeps being ascribed more and more mechanisms. What are the properties that you are aware of? Topiramate is probably under-utilized because of its liabilities for cognitive
side effects and kidney stones if it is not administered carefully. If dosages are kept between 100mg and 200mg and the drug is titrated very gradually, these can be avoided for the most part.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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