Posted by Chairman_MAO on October 1, 2011, at 15:18:54
In reply to Re: Parnate --) to split or not? » Ben, posted by europerep on September 30, 2011, at 7:47:17
> > thanks for you great informations but at ultra high-doses isn't it acting so stimulant that you get too nervous and cant sleep any more?
>Yeah, that can be a drawback. But I had that at the lower doses just as badly; didn't notice much of a difference between the two, honestly. I always had to take something to sleep, sometimes even clonidine + something else.
> The question is whether you need a higher dose in the first place. Your opening post didn't sound like it, so I totally don't get ChairmanMAO's point that you *should* raise the dosage.
>The point is that high-dose tranylcypromine is a different animal at the higher doses, because ...
> At any rate, the splitting up of doses of Parnate is, as far as I know, only about sleeping issues and insomnia.
... tranylcypromine gets metabolized into other active drugs. Certain side effects diminish at the higher doses. Take it however it helps; if yo uhave to take it all in the morning to avoid insomnia, go for it, but I found that to be a lackluster solution because _it's not just an MAO inhibitor_.
> day, I think that's fine. And you said it, it's >the pharmacodynamic half-life that counts, so you >don't have to worry that your MAO levels are going up and down because you don't split the dose.
This is an MAO inhibitor. There are no "MAO levels going up and down" of any significance. This is not like moclobemide. Not irreversible like the hydrazines are either, but this is a red herring.
Best of luck.
poster:Chairman_MAO
thread:998259
URL: http://www.dr-bob.org/babble/20110925/msgs/998473.html