Posted by SLS on September 19, 2011, at 6:09:38
In reply to How long to give Parnate?, posted by Alpam on September 19, 2011, at 4:31:37
Effective dosage range for Parnate: 40mg-80mg
For most people, 40mg is the minimum dosage required to produce a stable antidepressant response. 80mg is about as high as one would want to go. Some doctors who have followed the historic use of Parnate will see that dosages in excess of 100mg will pull some people out of a treatment resistant depression. This "supratherapeutic" dosing strategy has been studied quite a bit by Jay Amsterdam, MD. Parnate has a very short half-life (1 - 4 hours). People who are rapid acetylators might need higher dosages to offset their higher rate of clearance of the drug. I have been on 140mg of Parnate, and found the drug to be very tolerable. I didn't respond well enough to this high-dose strategy to justify continuing it.
I would advise giving each dosage increase a minimum of 3 weeks to work before making a treatment adjustment.
I am currently taking:nortriptyline 150mg
Lamictal 200mg
Abilify 10mg
lithium 300mg* Viibryd will be added to this regime in one week.
My illness runs along the bipolar spectrum, but does not fit easily into BP I or BP II.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:997166
URL: http://www.dr-bob.org/babble/20110914/msgs/997167.html