Posted by SLS on September 18, 2011, at 6:49:48
In reply to Re: Antipsychotics Increasingly Prescribed for Anxiety » Zyprexa, posted by linkadge on September 18, 2011, at 6:00:23
> Anyhow, AP's can lose their effectiveness over time and in animal models they lead to brain shrinkage.
>
> Linkadge
Is there any speculation as to what the mechanisms are for APs causing brain shrinkage? Any mitochondrial stuff going on? How might Abilify compare to other APs regarding brain shrinkage; understanding that it is a partial agonist of D2 and 5-HT1a receptors?Thanks.
I guess you know by now that I discontinued Nardil once again for lack of a lasting robust improvement. The drug that I will be using to replace it with is Viibryd (vilazodone). I am going into this thing virtually blind in that I am not going to speculate what are its chances of working based upon what is known about the drug's mechanisms. I know that it is a SRI and 5-HT1a partial agonist, but I don't know what else it might do. My only concern is that both Abilify and Viibryd act as partial agonists of 5-HT1a receptors. Perhaps the two drugs bind selectively at different receptor populations (somato-dendrytic autoreceptors versus postsynaptic excititory receptors).
Currently:
nortriptyline 150mg
Lamictal 200mg
Abilify 10mg
lithium 300mg* To add Viibryd 40mg in 7 days.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:996329
URL: http://www.dr-bob.org/babble/20110914/msgs/997077.html