Posted by jedi on September 16, 2011, at 14:12:38
In reply to Re: older MAOI Vs. modern MAOI (like moclobemide), posted by Diego11 on September 16, 2011, at 13:14:38
> Thank you!
>
> I wonder if there is any clinical study or trial that compares the efficiency between Nardil/Parnate and Moclobemide in treatment of social anxiety disorder?
>
> Which according to you is better Nardil or Parnate(for SAD, GAD, social phobia) ?I have failed two trials on Parnate. I've been using Nardil for over a decade. I had serious, treatment resistant atypical double depression, and social anxiety. Nardil, augmented with a small dose of clonazepam is the "BOMB" for this diagnosis. Many other meds will fail. After they all fail, Nardil will still often work. In my not so humble opinion, Nardil should be 2nd tier for this diagnosis. Not the last resort! I am prejudiced!
I so wanted Parnate to work for me because of the weight gain from Nardil. In my 2nd trial, I had a rare spontaneous hypertensive episode on Parnate. Can't take it. Nardil is the more relaxing med anyway, and better for social and other anxieties. In my case there is a synergism between Nardil and clonazepam (they both affect GABA). In combination they are very effective on social anxiety. Because of memory issues, I'm on a slow downward taper on the clonazepam. I used 2mg for years. It has been a very slow taper and I'm down to .5mg after many months. In my opinion, this is the only right way to taper off benzos.
The chance of hypomania is large when first starting Nardil or Parnate. I had it and it felt great after being depressed for so long. It is not the true antidepressant affect of the MAOIs. You have to be very careful. Avoid major life decisions, large purchases, etc. Many MDs will stop treatment with hypomania. After I got through it once, it never happened again, even on restarts of Nardil. Google Jedi, hypomania at site:www.dr-bob.org for many posts on this subject.
Again, This is all just my opinion. But it comes from over a decade of experience with over 45 different combinations of meds. That said, everyone is different. What works for one, may not work for someone else.
Be Well,
JediAdditional studies:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963356/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856667/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/16891998
Jedi
Treatment resistant, atypical, double depression with social anxiety.
Nardil + clonazepam
poster:jedi
thread:996264
URL: http://www.dr-bob.org/babble/20110914/msgs/996929.html