Posted by pedr on August 24, 2011, at 20:33:51
In reply to Re: Nardil + Abilify. All good so far., posted by jono_in_adelaide on August 8, 2011, at 19:56:08
EMS == Extrapyramidal symptoms? No, I haven't experienced any of those yet although my OCD and anxiety have been sky-high from time to time.
Unfortunately after 2 weeks I began to feel flat, sad and a bit depressed again. As each day passed I could just feel my Mind turning negative and my mood degrading. A pretty galling experience after such dizzy heights.
So I upped the dose on Sunday to 5mg and it's only made things worse. I feel quite badly depressed and perpetually exhausted - quite the opposite of the activating previous 2 weeks when I was too buzzed, if anything.
So just now I looked up the Pharmacology of Aripiprazole and lo :
Aripiprazole displays linear kinetics and has an elimination half-life of approximately 75 hours. Steady-state plasma concentrations are achieved in about 14 days. Cmax (maximum plasma concentration) is achieved 35 hours after oral dosing.
~ upon starting Abilify, I found that it took 2-3 days (i.e. 75 hours) to notice a robust, appreciable response
~ I had noted feeling better 3+ hours after taking a dose
~ time to reach steady-state is equal to the period of time I felt good, after which I am feeling horridSo either I felt good because the Abilify was continually increasing in concentration in my blood and now feel awful because it's stopped increasing, or, I felt good because the plasma concentration levels were lower and now feel bad because they're higher.
I've decided to go down to 1.25mg a day as a consequence. I will post another update in due course.
Cheers,
Pedr
Treatment Resistant depression, anxiety, OCD: 13 years
IBS-C & GERD: 8 years
Current meds: 90mg Nardil, 300mg Zantac, 20mg Prilosec
poster:pedr
thread:993195
URL: http://www.dr-bob.org/babble/20110822/msgs/994784.html