Posted by larryhoover on August 9, 2011, at 14:33:12
In reply to selegiline + birth control = accidental megadose?, posted by iforgotmypassword on August 9, 2011, at 11:00:52
> wat the? (article below.)
>
> They say "female sex steroids" and I can't get the full text to figure out what they are putting under that definition. Birth control pills usually only have ethinyl estradiol (which has a lot of scary effects wrt the liver, but i thought mostly related to clots forming) and any one of a bunch of different progestins that are common.
>
> I take plain estradiol sublingually (4mg), and cyproterone acetate at 150mg, which is a very high dose as I am not taking it for birth control but rather as an anti-androgen in a transgender HRT regimen. Now I am worried taking selegiline will require dietary restrictions; is this true and is there any affordable away around this?
>
> -------
>
> The article:
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> Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids
>
> http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.1999.00891.x/abstractWow! You'd think somebody would have noticed this profound effect before this.
Using the link you provided, I clicked on the .pdf full text article, and it loaded for me.
The drugs you're using are not identical to any of those identified in this very small study. I don't have any way of knowing how generalizable these results might be. And I don't know where you could obtain the answer.
I wish I could help, but I'm sorry that I can't.
Lar
poster:larryhoover
thread:993278
URL: http://www.dr-bob.org/babble/20110809/msgs/993296.html