Posted by SLS on July 16, 2011, at 5:33:33
In reply to Low dose seroquel, curious..., posted by sleepygirl2 on July 15, 2011, at 17:32:06
> I take 50mgs. I swear that if I take it less or not at all I get a bit speedy, overactive. I don't understand. People say it's just acting on histamine.
What people say this?
These people are wrong.
Although Seroquel (quetiapine), like clozapine (the most powerful antipsychotic), has a low affinity for D2 receptors, the higher dosages used do provide for sufficient receptor occupancy. This is accomplished as the average momentary percentage of D2 occupancy produced by quetiapine and its metabolite, norquetiapine, when used at therapeutic dosages, is comparable to other antipsychotics. This occurs as the quetiapine and norquetiapine molecules hop on and off the D2 receptors at a rate sufficient to allow for a net therapeutic response.
I would use the suggestions of others as a starting point for guiding your own research elsewhere on the Internet. For issues that are important to you, the time invested is well worth it.
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http://www.ncbi.nlm.nih.gov/pubmed/12444812"Quetiapine dose was correlated with central dopamine D(2) occupancy,"
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http://en.wikipedia.org/wiki/Quetiapine
"DosageAt very low doses quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses (over 250 mg) quetiapine starts blocking significant amounts of dopamine receptors"
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- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:991096
URL: http://www.dr-bob.org/babble/20110714/msgs/991147.html