Posted by bleauberry on June 25, 2011, at 14:47:55
In reply to Research shows Nardil (phenelzine) neuroprotective, posted by zonked on June 24, 2011, at 12:09:29
> Interesting! -z
>
> http://www.mendeley.com/research/phenelzine-old-drug-hold-clues-development-new-neuroprotective-agents/
>
> Phenelzine: An Old Drug That May Hold Clues to The Development of New Neuroprotective Agents
> by E M MacKenzie, Mee-Sook Song, S M Dursun, Sara Tomlinson, K G Todd, G B Baker
>
>
> Abstract
>
> The monoamine oxidase (MAO)-inhibiting antidepressant phenelzine (PLZ) is also used in the treatment of anxiety disorders such as panic disorder and social anxiety disorder and has been shown to have neuroprotective actions in an animal model of transient forebrain ischemia. Phenelzine has multiple actions in addition to inhibition of MAO that may contribute to its pharmacological and therapeutic profile. These actions include inhibition of GABA transaminase and elevation of brain levels of GABA, effects on functional availability of glutamate, sequestration of reactive aldehydes, inhibition of primary amine oxidase and effects on brain-derived neurotrophic factor (BDNF). 2-Phenylethylidenehydrazine (PEH) has been identified as a major metabolite of PLZ and has also been shown to elevate brain levels of GABA, to sequester reactive aldehydes and to exert neuroprotective effects in a transient forebrain ischemia model."The actions of PLZ and PEH should be considered when designing future drugs for the treatment of psychiatric and neurologic disorders, particularly those involving neurodegeneration."
>Ok, so I separated the last sentence because I found it very curious. On one hand they are saying all these good things, extra bonuses, nardil does. Ok, so we have a cool substance. On the other hand they want to develop a substance that does what nardil does? Why? They already have a substance that does all that. It's called nardil.
I'm sure all our meds do a lot more stuff than we know much about. I remember seeing, for example, a genetic study of what zyprexa does. It turned on or up about 30 different genes, while turning down or off about 30 others. In addition to everything we know about nardil, I wouldn't be surprised if it is doing other stuff as well that we haven't even pinpointed yet.
That is some interesting research on nardil, by the way. Thanks for sharing that. I was particularly interested in the anti-aldehyde action, because in that family are some of the neuro toxic substances from chronic infections from lyme, candida, and others. On paper at least, nardil might be a good choice for those patients. And probably many others who don't know they are one of those patients but they are.
poster:bleauberry
thread:989308
URL: http://www.dr-bob.org/babble/20110619/msgs/989409.html