Posted by larryhoover on June 16, 2011, at 17:06:27
In reply to Re: Inactive ingredients/enteric-coating:do yourself » larryhoover, posted by SLS on June 16, 2011, at 16:42:34
> Hi Larry.
>
> I took Wellbutrin 900mg for over a month without any side effects other than it made me feel moderately worse.
>
> I took Parnate 80mg in combination with Wellbutrin 300mg without side effects other than the addition of Wellbutrin made me feel moderately worse.
>
> Parnate isn't Nardil. Is Nardil more apt to affect the kinetics of Wellbutrin than Parnate?
>
>
> - ScottI really don't know, Scott. From what I read about the pharmacokinetics and modes of metabolic processing and excretion, it looks like this is an idiosyncratic interaction. I suspect that there have been case reports filed with the FDA and/or the manufacturer, indicating that the problem can occur. It's not predicted by receptor activity or direct drug effects. I suspect it's a quirk of liver function, i.e. a genetic (un)luck of the draw.
Lar
poster:larryhoover
thread:986279
URL: http://www.dr-bob.org/babble/20110610/msgs/988367.html