Posted by desolationrower on June 14, 2011, at 20:01:22
In reply to Re: Wellbutrin works, but while withdrawing? » desolationrower, posted by SLS on June 13, 2011, at 20:14:08
> Hi d/r.
>
> > i can't think how this would happen with bupropion,
>
> Why would you deem bupropion any less capable of producing a withdrawal rebound improvement as is seen with other antidepressants, particularly the tricyclics?sorry, i wrote that literally, not how it sounds now that i look at it. I meant, i cannot remember a mechanism. I have come across a few things on norepinephrine reuptake generally, but i can't remember it the way i can remember the 5ht story of "reuptake overloads presynaptic autoreceptors within hours, causing lowered 5ht release and firing rates until the autoreceptors desensitize and recede over the course of 1-3 weeks".
> > but there is the possibility that the immediate effects were negative
>
> I didn't feel immediately better or worse with bupropion. Its negative effects on my mood emerged before two weeks had expired, and persisted for the entire time I took it. Much of the relief I experienced upon discontinuation I attribute to a withdrawal rebound improvement. I repeated this experiment several time - mostly out of desperation.The other thing i remember about bupropion is the reduction of tnf-alpha levels. Usually that is good for energy, chronic disease, etc. perhaps for you, more tnf-alpha is good?
It is also somewhat active at some nicotinic receptor, but i didn't find much info on what it does when i looked into it. Have you monkeyed around much with ACHEis, nicotine, acetylcholine precursors?
> Regarding Parnate and watching for a spontaneous hypertensive crisis early in therapy, I may not have used the word "screen" properly. I was thinking that one could use a blood pressure measuring device and perhaps beware of hypertensive symptoms, although hypertension is often asymptomatic. Off the top of my head, I don't know if one could challenge the patient with a biological to determine sensitivity to Parnate.
>
>
> - Scotti just remember reading a CME or something about selegiline patch, and they did some sort of meals (probably just a juice or somehting) with specific amounts of tyramine, and looked for maybe 5 or 10 mm jump in bp.
it hasn't really ever been proven that spontaneous crisis involve tyramine though. i had a bp incrase eating an apple and having some tea about 5 hours before.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:987921
URL: http://www.dr-bob.org/babble/20110610/msgs/988121.html