Posted by jedi on June 8, 2011, at 0:14:40
In reply to Transition: Bupropion/venlafaxine to Nardil??, posted by Lamdage on June 7, 2011, at 15:40:35
Lamdage,
I would give the venlafaxine a full two week washout. It has a large effect on serotonin and mixing it with phenelzine without a long washout would be a serious mistake. Bupropion, on the other hand, is a different story. It has very little effect on serotonin. Though contraindicated, I have taken 90mg of phenelzine augmented with 300mg of bupropion with no trouble. I did start low and titrate slowly. Bupropion tends to make me aggressive, which is very unlike my normal personality. I'm not going to recommend that you take the two medications together. But I would think a long washout of bupropion would be unnecessary. Everybody is different, I would suggest researching it further. This is only my experience.
Jedi
http://www.dr-bob.org/babble/20060927/msgs/691100.html
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> Ok to the transition. It shouldnt be taken lightly although what the (non)experts say regarding Maoi.. well its way way overblown. Still its a very powerful med.
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> Like i said i can kick the venlafaxine out easily since it has like 20% of total AD activity in that mix. bupropion is way more effective for me. Question is.. how long does a significant SSRI action remain after cessation of the drug?
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> I dont wanna have serotonin syndrome or excess stimulation with bupropion. BUT and this is key: i do not want my underlying depression to get any worse so i want a transition as smooth as possible and i dont want to have a large timeframe where i go almost without AD(s).
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> Hoping for some knowledge input
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> Lamdage
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Jedi
Treatment resistant, atypical, double depression with social anxiety.
Nardil + clonazepam
poster:jedi
thread:986279
URL: http://www.dr-bob.org/babble/20110529/msgs/987433.html