Posted by Terry8 on June 7, 2011, at 9:55:01
In reply to Bupropion effects at 150-450 mg, posted by ralphrogers on June 7, 2011, at 7:17:33
>
> I've been raising bupropion dose from just 37 mg to 150 mg over the last weeks. Each time I raise the dose I seem to get stimulating benefits during the first days, but they fade away and I seem to get less motivated with time.The stimulating effects are not necessarily the same as the antidepressant effects. I know the energizing feeling you mean, and it's a nice feeling after being depressed, but if you chase that feeling it will go away after a few days at each dose. Once you reach the right dose for you, however, the antidepressant effects should kick in after several more weeks. Those probably won't be as obvious as the mildly speedy feeling when you first start bupropion; you simply feel better.
That's my experience, at least. I've found it takes some time to distinguish those first few days of feeling good on a new medication from the long-term continuous effects. Just because the first few days of stimulation don't last doesn't mean the drug has pooped out on you.
I was on 300 mg for the better part of a decade, then 400 mg for a couple years, and finally 450 mg for a short time. By the end it seemed like another medication would be better for me. But the experiences at different doses were the same. Whereas Remeron was a wildly different drug at different doses, due to effects on new neurotransmitters with dose increases, bupropion seemed pretty stable to me across the board; I just had to raise the dose over time as my depression worsened. As is the usual advice, find the lowest dose that works for you, and stop there.
poster:Terry8
thread:987336
URL: http://www.dr-bob.org/babble/20110529/msgs/987340.html