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Re: Why do some norepinephrine drugs cause anxiety??

Posted by mtdewcmu on May 7, 2011, at 13:13:28

In reply to Re: Why do some norepinephrine drugs cause anxiety??, posted by SLS on May 7, 2011, at 9:46:55

> Have you tried to raise the dosage of Effexor to 300mg? I would try that first. If you tolerate the dosage and you are still dissatisfied with the results, you can then add nortriptyline to boost NE along with its other effects on 5-HT2a blockade, etc.

That's a good conservative way to explore the NE hypothesis.

>
> Reboxetine is less likely to give you results than the tricyclics. It is usually more anxiogenic than desipramine.

Drugs that don't do well in studies are usually not worth bothering with (other than as 4-th, 5-th, nth-line treatments). The FDA evidently thought this about Reboxetine. Neurotransmitter theories are only useful insofar as they are backed up with evidence.


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Not a doctor. Contact a doctor for medical advice.
20mg citalopram, 40mg d-amphetamine, 15mg mirtazapine, 300mg bupropion
dx: chronic MDD, probable ADHD (inattentive)


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URL: http://www.dr-bob.org/babble/20110502/msgs/984802.html