Posted by desolationrower on May 6, 2011, at 4:51:36
In reply to Can ASA or NSAIDS Decrease Your SSRI?, posted by Phillipa on May 5, 2011, at 23:26:01
here is a link to the abstract: http://www.pnas.org/content/early/2011/04/20/1104836108.short
Obviously, the STAR*D data can be seen the other way, that if you were taking an NSAID and still in the trial (still depressed), that can be seen as another medication failure (the NSAID didn't cause remission). and the more med failures, the lower the response rate.
It does seem plausible: the rodent data is interesting. I would guess there might be an issue of the NSAID reducing arachadonic acid metabolites which are involved in learning. So basically you can't ahve enough of a stress for your brain to say, 'hey this is IMPORTANT' and rewire itself to include the new, non-depressed memory. AA has shown benefits for senility, for example.
iti reminds me of the benefits yohimbe show for relearning (there is a specific term i'm not rememberig, lol) anxiogenic memory, even though on its own, it increases panic.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:984688
URL: http://www.dr-bob.org/babble/20110502/msgs/984702.html