Posted by bleauberry on May 2, 2011, at 16:31:45
In reply to LDN, posted by ihatedrugs on May 2, 2011, at 9:58:25
LDN can indeed be amazing. I think more often than not it is helpful enough to keep on board, but not a total cure. Then again, sometimes, it is magic.
Since it first became trendy among the mysterious-disease crowd a few years ago, new things have been learned about it. For example, the 1.5mg to 4.5mg doses are not set in stone. Some people do best on much lower doses. Some people do well taking it during the day rather than at bedtime.
Heroine addicts claim it prevents tolerance, poopout, and withdrawal of their opiate highs. But....the dose that does that is 1/10th of 1mg taken at the same time as their illicit drug. The point I'm trying to make here is that LDN can do profound things even at doses that would totally confound someone who thinks only terms of scientific explanation.
My best dose is 1/8th of a 1.5mg capsule taken between 10am and 2pm. Various attempts at experimentation were the only way to discover that for myself. The lowest dose of 1.5mg did make me more depressed and quite anxious. Very uncomfortable.
I find it stunning such a tiny amount could have such power. But someone else might go straight to 4.5mg with no problem.
My first go round with LDN I started with 1.5mg. I did feel like crap but persisted. It was hard. About 2 weeks into I noticed I was having sporadic random moments during the day of feeling quite good....energy, mood, social. It was great. The rest of the time though was so bad I just couldn't hang in there and keep going with it.
Over the years I have developed sort of an inner sense to tell if something is within the serotonergic realm, NE realm, or dopaminergic realm. Though I cannot find any literature backing up my thoughts, I am convinced it has some kind of dopaminergic involvement. Maybe that's why one of the common starting side effects is insomnia or bizarre dreams?
NE....no. Serotonin....maybe a very slight distant touch.One wife at a forum said her husband was much better on LDN but still depressed. The addition of DLPA to LDN erased his longstanding depression right away. Maybe some synergy?
Anyway, for any psychiatric patient I am a huge fan of LDN. If they are willing to subject themselves to strong doses of psych meds, LDN is a cakewalk in comparison. And in my opinion has equal or greater potential to help the person compared to any psychiatric med on the planet. I just think that the dosing and timing takes extreme importance. I discovered in an unpleasant way that a common dose could indeed make me feel like hell and death, but that a different dose was friendly. Bedtime dosing was aweful for me, waking up almost in tears I felt so depressed. But daytime dosing was harmonious.
Our own opioid and endorphin system is intricately involved with all sorts of biologies within us....mood, energy, pain, immune function, disease in general. Though we may not be able to explain in or accurately test it, we can see in forums all around the world the amazing potential it has. You don't see those same kinds of "trends" with any other psych meds except maybe the old Nardil formula.
I would go as far as to say this. It makes no sense to not try it. Just play with the dosing and timing and plan on some time to see results. Disease is not quickly turned around.
poster:bleauberry
thread:984336
URL: http://www.dr-bob.org/babble/20110502/msgs/984385.html