Posted by SLS on April 13, 2011, at 6:22:41
In reply to Re: Pristiq + Wellbutrin anyone? » SLS, posted by Bob on April 13, 2011, at 0:51:14
> Scott,
>
> Have you ever spent a significant length of time on a therapeutic level of bupropion?
>
> BobHi Bob.
Good thought.
Yes, I have been on Wellbutrin 900 mg for a month or more on an open-label basis before it was finally approved by the FDA. I have tried it several times subsequently; each of which exacerbated my depression moderately. At the time, I thought that Wellbutrin was dopaminergic. That was my reason for trying it. Of course, we have learned since that it is not a potent dopamine reuptake inhibitor.
As an aside, I did respond briefly, but robustly to nomifensine (Merital), a potent DA reuptake inhibitor that is no longer available. If I were to add anything to Pristiq, it would be nortripyline. I tried Effexor in combination with nortriptyliine with partial success. Unfortunately, we stopped titrating nortriptyline at 75mg. We later found that I need 150mg. If I need to change strategies, I would try adding Pristiq 100mg to nortripyline 150mg. Who knows, perhaps the right dosage of Pristiq is 200mg for some people. Clinical experience is sparse at such high dosages. However, it took many years before dosages of Effexor of 300mg and higher were accepted as therapeutic.
- Scott
> > Pristiq + Wellbutrin
> >
> > I'm curious if anyone has tried this combination. I know one person who has been responding well to it, although it has only been a few weeks.
> >
> > I hope it lasts for her.
> >
> >
> > - Scott
>
>
>
> Scott,
>
> Have you ever spent a significant length of time on a therapeutic level of bupropion?
>
> Bob
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:982583
URL: http://www.dr-bob.org/babble/20110406/msgs/982636.html