Posted by SLS on April 10, 2011, at 5:26:00
In reply to Re: short question re: AP's + rispedal, posted by Christ_empowered on April 8, 2011, at 22:41:06
> I dunno...Abilify is strange b/c of the anxiety+agitation+akathisia. Seroquel at low doses is like a super sedating antihistamine, not so much an antipsychotic (it'd be cheaper to just take hydroxyzine or benadryl).
That might be a bit of an exaggeration. I saw someone have a miraculous recovery from a mixed-state once Seroquel 50 mg was added to Risperdal. That's no antihistaminic effect.
Regarding Abilify, it is my guess that it reduces the efficacy of coadministered antipsychotics due to its high affinity for D2 receptors and D2 partial agonism. It probably outcompetes antipsychotics with a low affinity at D2 receptors and would create a situation where the other AP is rendered ineffective or needs to be increased in dosage. Seroquel is a prime example of this. I know one woman for whom Seroquel 900 mg was only partially effective. Once Abilify 30 mg was discontinued, Seroquel 400 mg worked its magic.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:982265
URL: http://www.dr-bob.org/babble/20110406/msgs/982386.html