Posted by desolationrower on April 8, 2011, at 13:31:45
In reply to Wellbutrin plus Buspar, posted by Peter Heuer on April 8, 2011, at 10:43:41
> I have just started on Wellbutrin plus Buspar, but I have become uncertain about this combo.
>
> Here's what Roger Gould writes about Wellbutrin plus Buspar on medhelp.org:
>
> Both of these medications directly affect the same brain receptors, so it is very likely that there would be a cumulative effect that may be toxic rather than the supplemental effect you are hoping for. These medications are used to supplement ssri's because they target different receptors. They are not recommended to be used together.
>
> I have no doc to advise me, so I'm a little worried.
>
> I would like to hear from anyone who has an opinion about this combination of drugs.
>
> Best regards,
> Peter HeuerNo, this person was wrong. They aren't totally out to lunch, since buspirone was orginally developed to be an antipsychotic, and has some antagonistic activity at D4 receptors i think. But thats at a higher dose than used normally (and i wouldn't call the interaction 'toxic' either).
The are both somewhat proconvulsive, perhaps that was the thought?
It doesn't sound like a typical combination or one with special synergy, but i could imagine cases where this might be the best choice for someone's particular needs.
-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:982248
URL: http://www.dr-bob.org/babble/20110406/msgs/982259.html