Posted by desolationrower on March 30, 2011, at 12:51:06
In reply to Re: Nortriptyline vs reboxetine, posted by bleauberry on March 29, 2011, at 15:30:31
the 'danger' was reboxetine being ineffective. if there is a difference, nortrityline is more effective, and thus less 'dangerous' by that standard. i'm not interested in that article, though.
nortriptyline is a dirtier drug, specifically as an 5ht2 antagonist. good or bad depends on which of your two anxieties is more in need of help (change to nort if you want less GAD):
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Role of the amygdala and periaqueductal gray in anxiety and panicAbstract
The amygdala (AM) and the periaqueductal gray (PAG) represent the rostral and the caudal pole, respectively, of a longitudinally organized neural system, that is responsible for the integration of behavioral and physiological manifestations of defensive reactions against innate and learned threats. Microinjection of benzodiazepine (BDZ) anxiolytics, GABAA receptor agonists or 5-HT receptor antagonists into the AM has anxiolytic effects in conflict tests and other models of conditioned fear, while similar administration of 5-HT or of a 5-HT1A receptor agonist has anxiogenic effects. On the other hand, in the test of electrical stimulation of the PAG, microinjection of 5-HT, 5-HT mimetics, or of drugs that enhance the action of endogenous 5-HT into the same brain area has an antiaversive effect, like BDZ and GABAA agonists. Furthermore, microinjection of midazolam, of the NMDA receptor antagonist AP-7, or of the Image receptor blocker propranolol increased the exploration of the open arms of the elevated plus-maze, having therefore an anxiolytic effect. These results point to an inhibitory role of the GABA-BDZ system in both the AM and the PAG. In contrast, 5-HT seemingly enhances conditioned fear in the AM, while inhibiting unconditioned fear in the PAG. Thus, Image antagonists reportedly release punished behavior when injected into the AM, whereas they antagonized the antiaversive effect of 5-HT, zimelidine and Image receptor blockers in the PAG. Since reported clinical studies revealed that one of such compounds, ritanserin, relieves generalized anxiety but tends to aggravate panic disorder, a relationship may be established between the AM and anxiety and the PAG and panic.
*******-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:981366
URL: http://www.dr-bob.org/babble/20110321/msgs/981469.html