Posted by mtdewcmu on March 22, 2011, at 21:56:22
In reply to Re: What is anafranil 'actually' doing for me ? » mtdewcmu, posted by Phillipa on March 22, 2011, at 21:05:53
Are you saying that because Luvox is FDA approved for OCD? My guess is that most any antidepressant could get approved for OCD, it's just a matter of which drug companies go through the process. Doctors can prescribe any drug off-label for OCD, so getting FDA approval is a matter of costs versus profits for the drug company. Luvox is unpopular, so it was probably worth getting it approved.
I didn't look up the data on Anafranil before I mentioned NE, I just assumed that since tricyclics are "dirty" drugs it would hit NE. According to wikipedia, Anafranil is about 385 times more potent at 5-ht than NE. Wikipedia also says Luvox is about 100 times more potent at 5-ht than NE. So, ironically, Luvox is less selective for 5-ht over NE than Anafranil. Don't even try to rationalize it; psychiatry is not a precise thing. We can speculate about reasons, but that's all.
> Glad you responded to Kizzie. If anafranil is both norepenphrine and serotonin for Ocd how come Luvox is only serotonin? Phillipa
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