Posted by sukarno on February 2, 2011, at 15:24:59
In reply to what does triazolo- mean? (nm), posted by floatingbridge on January 31, 2011, at 17:15:41
Triazolobenzodiazepines are BZD analogs. The triazole ring prevents the generation of long-acting metabolites (e.g. it causes the drug to be metabolized quickly. In other words, it will be short-acting).
Most, if not all, TBZDs end with "lam".
Alprazolam, estazolam, triazolam, etc.http://www.springerlink.com/index/w6219425527n6rt5.pdf
"Alprazolam is a benzodiazepine analog
characterized by a triazole ring. The
ring prevents the oxidative metabolism
responsible in other benzodiazepines
for the generation of long-lived metabolites
(Cohn 1981). In controlled trials, anxious
patients reported daytime sedation significantly
less frequently with alprazolam than with
equivalent doses of the longer-acting diazepam
(Evans 1983; Dawson et al. 1984)."Rx: alprazolam 1mg QID, famotidine 20mg BID, cetirizine 10mg BID, GNC Ultra Mega Gold vitamin supplement BID
Dx: panic disorder with agoraphobia, chronic depression, probable PTSD
poster:sukarno
thread:976654
URL: http://www.dr-bob.org/babble/20110130/msgs/978553.html