Posted by rovers95 on January 21, 2011, at 11:27:20
In reply to Re: Depression still in remission on cetirizine » sukarno, posted by Conundrum on January 17, 2011, at 15:08:17
> I think the only way to stop the anhedonia, would be to stop taking the drugs, or maybe add a stimulant. Xanax can cause anhedonia, as can strong D2 receptor blockade.
> > I thought I would report back now (over a month later) that my depression is in remission on cetirizine. I began taking it in early December for allergies.
> >
> > I haven't used my light box ever since I began taking cetirizine (Zyrtec / Reactine).
> >
> > I told my pdoc about this and his opinion was that it was not the cetirizine itself, but rather that the cetirizine is potentiating the effects of alprazolam (Xanax).
> >
> > He could be wrong, but do you think he is right?
> >
> > The downside is that I feel some anhedonia, a general sense of boredom and dramatically lowered libido.
> >
> > Maybe Xanax is causing cetirizine to cross the blood brain barrier? Hydroxyzine, the parent drug, is a dopamine D2 antagonist and I think it also blocks some type of 5-HT (serotonin) receptor.
> >
> > I have no idea what is going on in terms of drug interactions, but cetirizine is working, even if that is only because it is potentiating the effects of alprazolam.
> >
> > I just wish I had some interest in things. I feel like sitting around and doing nothing. I don't feel particularly happy or sad about anything.
>
>I felt amazing on cetirizine...but also very stimualted...(manic?!) Congrats anyway...and perhaps you should try diching the xanax...let us know hopw you get on!!!
Rover
poster:rovers95
thread:952158
URL: http://www.dr-bob.org/babble/20110115/msgs/977596.html