Posted by jerryTRD on December 29, 2010, at 16:35:24
In reply to *Not* Thinking in terms of meds, posted by linkadge on December 17, 2010, at 18:19:43
I just found this article:
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Placebos workeven without deception
FINDINGS:
Patients who were knowingly given placebos for irritable bowel syndrome experienced significant symptom relief when compared with controls.RELEVANCE:
The fact that placebos may work even when individuals are fully knowledgeable that they are not taking an active drug may bypass the ethical dilemma of deceiving patients.Patients who were knowingly given placebos for irritable bowel syndrome experienced significant symptom relief when compared with controls.
BOSTON, Mass. (Dec. 22, 2010) For most of us, the placebo effect is synonymous with the power of positive thinking; it works because you believe youre taking a real drug. But a new study rattles this assumption.Researchers at Harvard Medical Schools Osher Research Center and Beth Israel Deaconess Medical Center (BIDMC) have found that placebos work even when administered without the seemingly requisite deception.
The study is published December 22 in PLoS ONE.
Placebosor dummy pillsare typically used in clinical trials as controls for potential new medications. Even though they contain no active ingredients, patients often respond to them. In fact, data on placebos is so compelling that many American physicians (one study estimates 50 percent) secretly give placebos to unsuspecting patients.
Because such deception is ethically questionable, HMS associate professor of medicine Ted Kaptchuk teamed up with colleagues at BIDMC to explore whether or not the power of placebos can be harnessed honestly and respectfully.
To do this, 80 patients suffering from irritable bowel syndrome (IBS) were divided into two groups: one group, the controls, received no treatment, while the other group received a regimen of placeboshonestly described as like sugar pillswhich they were instructed to take twice daily.
Not only did we make it absolutely clear that these pills had no active ingredient and were made from inert substances, but we actually had placebo printed on the bottle, says Kaptchuk. We told the patients that they didnt have to even believe in the placebo effect. Just take the pills.
For a three-week period, the patients were monitored. By the end of the trial, nearly twice as many patients treated with the placebo reported adequate symptom relief as compared to the control group (59 percent vs. 35 percent). Also, on other outcome measures, patients taking the placebo doubled their rates of improvement to a degree roughly equivalent to the effects of the most powerful IBS medications.
I didnt think it would work, says senior author Anthony Lembo, HMS associate professor of medicine at BIDMC and an expert on IBS. I felt awkward asking patients to literally take a placebo. But to my surprise, it seemed to work for many of them.
The authors caution that this study is small and limited in scope and simply opens the door to the notion that placebos are effective even for the fully informed patienta hypothesis that will need to be confirmed in larger trials.
Nevertheless, says Kaptchuk, these findings suggest that rather than mere positive thinking, there may be significant benefit to the very performance of medical ritual. Im excited about studying this further. Placebo may work even if patients knows it is a placebo.
This study was funded by the National Center for Complementary and Alternative Medicine and Osher Research Center, Harvard Medical School.
Written by David Cameron.
Full article
http://hms.harvard.edu/public/news/2010/122210_kaptchuk/
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Especially the quote: "Nevertheless, says Kaptchuk, these findings suggest that rather than mere positive thinking, there may be significant benefit to the very performance of medical ritual."Am I on the same page as you Link or am I way off?
-Jerry
Depression, chronic & severe, recurrent, treatment-resistant w/GAD.
Meds: Effexor XR 300mg, Adderall IR 20mg 3x daily, Klonopin 5mg, Seroquel 400mg, Ambien 10mg, Synthroid 150mcg, Androgel
poster:jerryTRD
thread:973794
URL: http://www.dr-bob.org/babble/20101218/msgs/975169.html