Posted by Ron Hill on December 1, 2010, at 22:51:24
In reply to Re: Circadian Clock Linked To Depression Mood » Ron Hill, posted by alchemy on December 1, 2010, at 20:32:02
Alchemy,
> I did a 2-3 week trial and if there was an effect it was more negative. I'm glad it worked for you. It makes sense because it works on circadian stuff.
Rapid cycling is directly associated with circadian rhythm dysfunction. That's why I hoped Valdoxan would help you. I'm sorry that it did not work. I'm also sorry for the money you spent on the Valdoxan purchase.
> btw- yesterday my dr. said he think we have pretty much exhausted everything & to make no changes.With all due respect, I disagree with your p-doc.
> On one had he is right, I've been through the ringer. He has been a pretty good doc. And trying a new med is a huge risk or me - I would say a 90% chance it will make me worse. And there is a problem is the withdrawal and my body trying to re-adapt. Med trials are what have pushed me into needing ECT.
I hear what you are saying, but I'm concerned that Celexa may be contributing to your rapid cycling. Dexedrine may also be contributing to your rapid cycling.
As you know, it is still on my list to reply in full to our post exchange in a prior thread. I don't have time to do that tonight, but I will try to get to it this weekend.
You still are taking the following, correct?
400 mg/day Lamictal
30 mg/day Celexa
2 mg/day Xanax
300 mg/day Wellbutrin
Synthroid
DexedrineHow much Dexedrine are you taking?
Are you taking instant release or Dexedrine Spanules sustained release?
Remind me why you are taking Dexedrine? Do you take it to treat low energy?
How much synthroid are you taking?
How long has it been since you had your TSH tested?
What is your TSH level?
If it were me, I'd start by adding 600-900 mg/day of Trileptal and raise it if needed to 1200-1800 mg/day.
Next, I would slowly wean off of Celexa, Wellbutrin, and Dexedrine. After the two-week washout, I'd add Parnate and ramp it up to 60-80 mg/day.
If Parnate didn't work, I'd switch to Nardil but I'd guard against weight gain right from the start of taking Nardil.
Once the MAOI is fully ramped up, VERY LOW DOSAGES of Wellbutrin and/or Dexedrine might be able to be added VERY CAREFULLY.
That's what I'd do if it were me, but I'm not you.
More later.
-- Ron
dx: Bipolar II and mild OCPD600 mg/day Trileptal (oxcarbazepine)
200 mg/day Lamictal (lamotrigine)
500 mg/day Keppra (levetiracetam)
90 mg/day Nardil (phenelzine)
12.5 mg every other day Valdoxan (agomelatine)
3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
2.5 mg/day Adderal XR45 ml/day of Carlsons Bottled Fish Oil
100 mg/day phosphatidylserene
1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
2000 IU/day Vitamin D-3
850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
200 mcg/day GTF Chromium
600 mcg/day Chromium Picolinate
200 mg/day Co-Q10
1000 mg/day Cinnamon
480 mg/day Milk Thistle
2 g Vitamin C
Whats next to add?:NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid
poster:Ron Hill
thread:970722
URL: http://www.dr-bob.org/babble/20101117/msgs/972141.html