Re: Simple Question But Can't Understand

Posted by ed_uk2010 on October 27, 2010, at 17:26:15

In reply to Re: Simple Question But Can't Understand, posted by Phillipa on October 26, 2010, at 20:59:48

> What about say bacterial meningitis? Just the spinal fluid? But doesn't that pass through brain stem via spianl columm into the brain? Meds are really complicated. Phillipa
I'm not sure what the question is... but the permeability of the blood brain barrier is increased in bacterial meningitis. Antibiotics such as penicillin G and cefotaxime which normally penetrate poorly are able to penetrate relatively well during the acute phase of the illness. A small number of antibiotics such as chloramphenicol penetrate the BBB very well. Due to the risks of chloramphenicol injection, it is only used occasionally - for life threatenening infections. IIRC, sulfonamines penetrate the BBB very well. Back in the days when meningococci were highly sensitive to sulfonamines, they were very effective for meningococcal meningitis.

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Simple Question But Can't Understand Phillipa 10/26/10
Re: Simple Question But Can't Understand ed_uk2010 10/26/10
Re: Simple Question But Can't Understand bleauberry 10/26/10
Re: Simple Question But Can't Understand Phillipa 10/26/10
Re: Simple Question But Can't Understand ed_uk2010 10/27/10
Re: Simple Question But Can't Understand » ed_uk2010 Phillipa 10/27/10

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