Posted by benzo85 on October 1, 2010, at 18:26:26
In reply to Would Nardil be..., posted by Conundrum on September 26, 2010, at 18:59:25
Positive effects at 15/d were transient at best.. I bumped up to 45/d for meantime and it's definitely better. I have read of people being fine or even going hypomanic on 15/d, which is pretty crazy, imo; but everyone's different. Perhaps on the old formulation 15/d actually did something for most people and was a suitable maintenance dose, but presumably that was after 'remission' was achieved and maintained for an adequate period with a higher dose.
Here's interesting snippet:
Continuation and maintenance treatment of major depression with the monoamine oxidase inhibitor phenelzine: a double-blind placebo-controlled discontinuation study.
Robinson DS, Lerfald SC, Bennett B, Laux D, Devereaux E, Kayser A, Corcella J, Albright D.
Bristol-Myers Squibb Company, Wallingford, CT 06492.
AbstractLong-term treatment with antidepressant drugs has received little attention until recently. A study is reported comparing the effectiveness of maintenance treatment with phenelzine in responding major depression patients. If they responded initially to nonblind phenelzine treatment and sustained remission for 16 weeks, patients were randomized to 2-year double-blind treatment with phenelzine 60 mg/day, phenelzine 45 mg/day, or placebo. Both doses of phenelzine were significantly better than placebo in preventing relapse of depression. Phenelzine 45 mg/day may be an optimal maintenance dose for many patients.
poster:benzo85
thread:963894
URL: http://www.dr-bob.org/babble/20100926/msgs/964422.html