Posted by g_g_g_unit on September 29, 2010, at 23:37:22
In reply to Re: miserable » g_g_g_unit, posted by ed_uk2010 on September 29, 2010, at 14:52:36
> I believe that it's a very weak D2 antagonist but I doubt that that's responsible for your current symptoms. Muscle twiching and exaggerated reflexes in the legs are typical of potent serotonergic drugs. I think it's a sign that the dose is excessive. Metabolism of clomipramine is extremely variable and dosage requirements vary substantially from person to person. Don't worry about taking any particular 'target dose', just find the dose which reduces your symptoms without causing unacceptable side effects.
>Ah okay. I had been told that it's a moderate D2 antagonist.
Strangely, I'm finding that the drug has vastly different properties at different doses. At 100mg, I was disorientated, foggy, and prone to slurring my speech, whereas reducing the dose to 25-75mg seems to bring on a potent NRI effect that is not entirely dissimilar to my Ritalin experiments. I get bad muscle tension, a feeling of being strangely immersed in my environment (to the point of occasional dissociation), and a kind of weird scrambling of my working memory, despite feeling more alert overall. I may be talking out of my butt, but does that sound like too much noradrenaline in the frontal cortex?
I also wish I knew why this lower dose was still wrecking my sleep. I never awaken fully enough to know whether it's the muscle twitching, but I have this feeling of watching myself sleep the whole time. I've tried 75mg all at night, and 50mg in the night + 25mg in the morning, but it makes no difference. Are there some people who take it all in the morning?
Thanks again for your continued support and advice! :)
poster:g_g_g_unit
thread:963674
URL: http://www.dr-bob.org/babble/20100926/msgs/964268.html