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Trk-b sigma-1r

Posted by linkadge on August 29, 2010, at 21:01:59

Agents which act as both trk-b agonistand sigma-1r agonists would exhibit potent neurotrophic activity.

Fluvoxamine is a sigma agonist but not a trk-b agonist. Amitriptyline is a potent trk-b agonist but has lesser effect on sigma receptors.

what about combining fluvoxamine and amitriptyline? This would theoretically be potently neurotrophic.

Linkadge

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URL: http://www.dr-bob.org/babble/20100829/msgs/960547.html