Posted by Conundrum on August 26, 2010, at 20:13:56
In reply to Re: severe depression 30 minutes after masturbation » Conundrum, posted by Tomatheus on August 26, 2010, at 18:32:06
Its debatable whether wellbutrin's mechanism of action is really from reuptake inhibition.
from wikipedia's entry on bupropion
"The occupancy of dopamine transporter (DAT) by bupropion and its metabolites in the human brain as measured by positron emission tomography was 622% in an independent study[124] and 1235% according to GlaxoSmithKline researchers.[125] Based on analogy with serotonin reuptake inhibitors, higher than 50% inhibition of DAT would be needed for the dopamine reuptake mechanism to be a major mechanism of the drug's action. By contrast, approximately 65% occupancy or greater of DAT is required to achieve euphoria and reach abuse potential.[126]"Originally wellbutrin probably did have some efficacy as a reuptake inhibitor when people were dosed between 600-900mgs but the seizure threshold was lowered to much.
Wellbutrin's mechanism of action probably has something to do with its NDRI properties but it also from its effects on nitric oxide and nicotine receptors.
Nardil would definitely increase dopamine and norepinephrine more than wellbutrin and keep it around longer afterwards.
Iatrogenic post-SSRI problems: anhedonia, memory and concentration problems, sexual dysfunction. (not a formal DX)
Country:USA
Currently taking Lamictal, mirtazapine, and abilify.
poster:Conundrum
thread:959831
URL: http://www.dr-bob.org/babble/20100821/msgs/960068.html