Posted by ed_uk2010 on July 5, 2010, at 0:54:08
In reply to Re: Potency of clomipramine? - very high!, posted by SLS on July 4, 2010, at 18:50:43
>It goes against what I have been taught, but I don't know the details as to how the dosage ranges for these drugs were arrived at.
Part of the problem seems to have been that when new TCAs (such as clomipramine) were brought out, it was assumed that they should be administered at the same dose as earlier TCAs. The huge variations in potency and receptor binding between the different TCAs doesn't seem to have been considered. Another problem was that doses were increased before giving lower doses a change to work eg. by titrating to 150mg over 2 weeks.
poster:ed_uk2010
thread:952518
URL: http://www.dr-bob.org/babble/20100628/msgs/953338.html