Posted by jedi on July 3, 2010, at 2:36:44
Hi Guys,
I've read some posts recently about the possible long term brain damage caused by the hydrazine derivative phenelzine(PLZ). As a user of phenelzine for over a decade, that concerns me. Here is a study that shows the possible neuroprotective effect of phenelzine and it's major metabolite, phenylethylidenehydrazine(PEH).
JediSummary:
"Studies on the mechanisms of action and metabolism of PLZ suggest that the clinical application of PLZ should be wider than it already is (e.g. should it be used in post-stroke depression and in Alzheimers disease?) and that analogues of PLZ and PEH should be developed as potential new drugs for treating psychiatric and neurologic disorders, particularity those involving neurodegeneration."Abstract:
The monoamine oxidase (MAO)-inhibiting antidepressant
phenelzine (PLZ) is also used in the treatment of anxiety
disorders such as panic disorder and social anxiety disorder
and has been shown to have neuroprotective actions in an
animal model of transient forebrain ischemia. Phenelzine
has multiple actions in addition to inhibition of MAO that
may contribute to its pharmacological and therapeutic
profile. These actions include inhibition of GABA
transaminase and elevation of brain levels of GABA, effects
on functional availability of glutamate, sequestration of
reactive aldehydes, inhibition of primary amine oxidase
and effects on brain-derived neurotrophic factor (BDNF). 2-
Phenylethylidenehydrazine (PEH) has been identified as a
major metabolite of PLZ and has also been shown to
elevate brain levels of GABA, to sequester reactive
aldehydes and to exert neuroprotective effects in a
transient forebrain ischemia model. The actions of PLZ and
PEH should be considered when designing future drugs for
the treatment of psychiatric and neurologic disorders,
particularly those involving neurodegeneration.Full text:
http://www.psikofarmakoloji.org/pdf/20_2_13.pdf
Jedi
Treatment resistant, atypical, double depression with social anxiety.
Nardil + clonazepam
poster:jedi
thread:953079
URL: http://www.dr-bob.org/babble/20100628/msgs/953079.html