Posted by linkadge on July 2, 2010, at 19:56:52
In reply to Re: The biology of depression » linkadge, posted by jade k on July 1, 2010, at 19:47:07
>I know from experience that the above is true. >But in the case of siezure activity and mania >that presents as rage, is it still SD/dopamine >related? If not, fatigue and exhaustion don't >seem to fit as both conditions (siezure, manic->rage) look like a kind of hyper active state has >been triggered.
>So what has the SD caused in these cases (if not >dopamine activity)?
Hard to say - I really don't know enough. There is more involved in the AD effect of sleep deprivation than just dopamine augmentation.
A boost in thyroid (as can occur with SD) would augment serotonergic / noradrenergic function. Thyroid can sometimes increase irritability. Studies suggest that SD increases the firing of DRN serotonergic neurons. This could increase irritability and / or the feelings of imperitiveness / goal directedness. I think there is some effect (slowing) on glutamate reuptake which could have an AD / proconvulsant effect. SD tends to be a PET activator, although decreases in limbic metabolism have also been noted too.
I know that when I miss a night of sleep, I get really driven to completely finish whatever it was that was bothering me enough to keep me up.
I personally think the efficacy of the MAOI's is partially due to the profound disruption of sleep cycles. I remember on parnate, I could only sleep about 3-4 hours and it was very broken. I started to become mildly psychotic and paranoid - scarry feelings. But at the same time it was great. I had never had such a complete resolution of anhedonia.
Linkadge
poster:linkadge
thread:952373
URL: http://www.dr-bob.org/babble/20100628/msgs/953023.html