Posted by SLS on June 12, 2010, at 6:46:28
In reply to Re: Valproic Acid Linked To Congenital Malformations, posted by linkadge on June 11, 2010, at 18:20:31
Hi Linkadge.
Thanks for taking the time to respond. I wish I had your memory. Maybe one day...
- Scott
> I know that gsk-3b inhibitors have mood stabilizing effects. Gsk-3b is increased by stress and attenuated by mood stabilizers (and some antidepressants like fluoxetine). It has some effect on circadian rhythms, neuronal inflammation as well as blood glucose regulation. GSK-3b inhibiton also affects the sensitivity of 5-ht1b receptors as well, GSK-3b inhibiton also reduces the developement of beta amyloid.
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> In terms of development of the fetus, not exactly sure. It has some effect on the outgrowth of nerve cells. Mild GSK-3b inhibition in humans appears to have neurotrophic effecs, while as higher doses are neurotoxic. It is linked somehow with beta catenin and bcl-2, which regulate cell survival, nerve growth etc. I'm not a molecular biologist though.
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> There is some info here (page 5) with regards to the effects of teratogenic effects of valproate. In this case it is in reference to its HDAC inhibiting effects.
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> http://www.biochemsoctrans.org/bst/037/1126/0371126.pdf
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> Linkadge
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The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:950624
URL: http://www.dr-bob.org/babble/20100604/msgs/950783.html