Posted by Brainbeard on May 27, 2010, at 13:01:25
In reply to Tricyclic Lovers: Desipramine or Pamelor, posted by bearfan on May 26, 2010, at 4:55:56
> Since Desimpramine (Norpramin) or Pamelor (Nortriptyline) tend to be the most common tricyclics nowadays, what tends to be the difference between the two? Is one better for anxiety and other for depression or are they very similar?
I don't know if they're the most common ones - not here in Holland, at least.. Desipramine has been abandoned completely here.
The drugs are very different. Desipramine is a very powerful and relatively pure NRI (Noradrenaline Reuptake Inhibitor), while nortriptyline is a much less potent NRI and has several other actions. Desipramine is almost like a stimulant, while nortriptyline is more like an anxiolytic (anxiety busting), sleep-promoting mild energizer (if it can even be called that..).
Desipramine can be a little rough on the heart, while nortriptyline is about the least side-effect ridden TCA there is.
Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.
poster:Brainbeard
thread:948932
URL: http://www.dr-bob.org/babble/20100524/msgs/949108.html