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Prozac + TCA: Keep Dose Low!? Trimipramine?

Posted by Brainbeard on May 26, 2010, at 4:56:58

In reply to Re: What would be a good TCA to add???, posted by desolationrower on May 23, 2010, at 17:52:37

Prozac inhibits the breakdown of TCA's very strongly, so maybe your dose of protriptyline is simply too high.

I found imipramine to be a cool add-on to Prozac in low doses (no higher than 25mg).

You could also try trimipramine, an atypical TCA with good antidepressant qualities which improves sleep architecture while intensifying REM-sleep (usually, AD's suppress REM-sleep.)


Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.


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poster:Brainbeard thread:948509
URL: http://www.dr-bob.org/babble/20100524/msgs/948934.html