Posted by Vic80 on May 24, 2010, at 19:12:52
Milnacipran 25mg x twice daily
Lorazepam 0.5 mg every 6 hours
Propranolol LA 20mg - took once 3 days ago - caused severe depression and malaise so ditched it.I am now on day 10. The anxiety is quite bothersome. And yes, its taken some seriously freaky shapes- being sacred of the dark, sacred to look at non-smiling faces, fear of going crazy, unreality, nervousness, semi panic attacks. Plus Tachycardia 120-130 bpm. Fortunately bp is not too high and my ECG came out normal too.
Mood seems to be better a few times, but there have been intermittent spells of dysphoria...the initial euphoric bouts are gone.
Propranolol LA was added to curb rapid pulse and anxiety, but the first dose itself caused me to feel extreme fatigue malaise and depression. So i am back on Lorazepam 0.5 every 4 hours though its not as calming as it should be.
I wonder if Lexapro quick taper (started at 10mg in January, upped to 20 in march, came down from 20mg to 0 in a month and half)could have had an effect too - still feel the shocks on my scalp.
A high pulse rate with anxiety seems to be crashing me, no Propranolol since the bad 1st dose.Almost feeling giddy and dazed, emotionally numbed or too overwhelmed. Wonder if the high NE is too much for me to take.
Beta Blockers are a new thing to me, after my one time experience with propranolol I am too scared to try any of them, though I have read that the lipophilic profile could decide their entry into the blood-brain-barrier to cause or exacerbate mood distrubances.
SO what option do I have, lorazepam has begun to poop out - i dont feel much relief on 0.5 and the doc is unwilling to go back on 1 mg, plus it also has begun to make me feel a bit depressed while it wears down after a few hours.
And I have also begun to feel the memory flashes, sudden deja-vu and jamais vu delirious feelings which I had on 20mg Lexapro.... wonder if this is too much serotonin causing this - generally comes around with inability to stay awake or asleep. In the past I had blamed it on the acetylcholine deregulation of escitalopram..... but apparently mil doesnt have much anticholinergic effect (but then thats comparing it to clomipramine and other TCAs)Some savella/ixel users have compared mil experience to wellbutrin - I am too sensitive to any sudden mood changes - including euphoria or elation or anything that could force me to have extra control over myself. Yet I do not want to feel the zombie effect of escitalopram - though I wonder if the Serotonin RI of MIL would eventually numb me out...
Does the NE RI help keep dopamine levels in check so as to not feel the emotional blunting and numbness SSRIs cause, then again people on SNRIs like Cymbalta and Effexor have complained about the emotional zombie states....
All I can say is, at the cost of sounding like a demanding kid, I want to feel not-depressed, not-anxious, yet have the ability to feel emotions, not feel dazed/drugged and most importantly have mental clarity.
I just hope Milnacipran turns out to be a good choice.My question is: what would be the best non-benzo non-beta-blocker option I can consider to tackle the tachycardia and anxiety? I seem to not work well with anything that makes me fatigued or sedates me.
Does the anxiety side effect last long enough or does the body get used to the extra NE?
poster:Vic80
thread:948662
URL: http://www.dr-bob.org/babble/20100524/msgs/948662.html