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Milnacipran- Irritability hyperactivity Mood Swing

Posted by vic80 on May 18, 2010, at 10:54:23

Lex Taper: down to 5mg today - 2.5 mg next 2 days and then stop.
Milnacipran: 25mg - 4th day

4th day on MIL and I am beginning to feel such a rollercoaster of moods that is freaking me out - start the day with feeling totally out of it, dull and trapped in my head, withdrawn, but energy levels are ok

After breakfast (thats when I take MIL and Lex) -
sudden elevation of mood and energy levels - over-active, talkative and confident - freaks me out either coz its some sign of that widely abused term hypomania or maybe I have just not been in good spirits for months.

The mood lasts for almost 1 hour, then starts to fizzle down a bit - I start to feel a bit irritated and short fused
another 1 hour : Feel the energy to do things, but not the drive or motivation - almost dissociative!
Antagonistic mood - bordering on agitation
Feeling very irritable now, mind feels frozen - cannot read write think or do anything - just anger - pacing up and down - almost at the verge of a violent outburst - but as though in control.

Calm down in a bit - spirits are pretty down - not calm - but dysphoric - uninterested - energy levels are down to zero.

Food tastes much better - appetite has improved - physical stimulation by external stimuli - like touch, the breeze etc.

Sudden interest in talking to people - cordial with underriding and quite apparent caustic bitterness.

Sudden apathy and disinterest. Mental suffocation.

Almost a hypnotic state of mind.

Evening and late evening - dysphoria and fatigue - emotional overdrive - feel like crying, hugging people.

Sudden ruminations of the past - unstoppable self observation

Enhanced motivation to do things - but fizzles out with the mood.

Sudden irritability again before dinner followed by stupor and brain-deadness.

Post-dinner - elevated spirits, very concerned for family, making animated interesting conversations. Depersonalization symptoms seem to lift a bit - able to interact emotionally with my environment, confident of my own thoughts and seem to not have a life of their own. FEELING A BIT DRUNK rather DOPED.

Followed by dip in energy levels and gradual dip in mood - by the time I am in bed to sleep - mood stablizes - Lorazepam 0.5 and I am off to sleep in 20 minutes.

Apart from this mind is constantly popping with songs from TV, mobile ringtones, words and phrases from conversations I have had in the day or been a part of, words stuck in my head - this is definitely Lex withdrawal.

This is a rather long drawn desciption of my experience on Milnacipran 4 days. Not to mention a pulse rate which doesn go down below 96.

The feeling of a rock in my head is reminiscent of Mirtazapine - and even the increase in pulse rate - maybe the NE increase.

WhatI am scared of is that on 20 mg lexapro - i had no energy, used to have feelings of unreality, memory flashes, deja-vu blurred vision and disconnection.
This went away after I tapered down to 10 mg.

I have had subtle similar feelings today - especially the drunk feelings and the casual deja-vu.

Is the high serotonin causing this?

NE could be behind the hyperactivity and irritability.

Any comments?



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poster:vic80 thread:947807
URL: http://www.dr-bob.org/babble/20100514/msgs/947807.html