Posted by SLS on May 11, 2010, at 6:58:04
In reply to Re: NARDIL Dosage Increase? » SLS, posted by pedr on May 10, 2010, at 23:10:40
> >> It interferes with its own metabolism, so a small increase in dosage can lead to a larger increase in levels of drug in the body.
>
> Hi Scott,
> would you mind elucidating this point, or pointing me at some literature?---------------------------------------------
http://www.druginformation.com/RxDrugs/P/Phenelzine%20Sulfate%20Tablet.htm
Metabolism Phenelzine is extensively metabolized, primarily by oxidation via monoamine oxidase. After oral administration of 13C6-phenelzine, 73% of the administered dose was recovered in urine as phenylacetic acid and parahydroxyphenylacetic acid within 96 hours. Acetylation to N2-acetylphenelzine is a minor pathway.
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Once substantial MAO inhibition is achieved, levels of Nardil build up as it is no longer metabolized except through acetylation, which is a minor pathway. It no longer follows the same kinetics as is seen in single-dose investigations.
> I don't understand why it must be taken daily when it takes 2 weeks for MAO to regenerate.
I know. It doesn't seem to make sense. However, I can attest to the fact that skipping even a day can lead to a lowering of mood and withdrawal symptoms, including REM rebound and anxiety.
- Scott
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:946832
URL: http://www.dr-bob.org/babble/20100504/msgs/947071.html