Posted by SLS on April 26, 2010, at 7:55:05
In reply to Re: Multiple drug exposures and treatment resistence » linkadge, posted by conundrum on April 26, 2010, at 7:13:21
> Guess thats me, the real reason I stopped prozac was that I didn't bother to get my script refilled and thought maybe I didn't need it anymore. Now I seem to be treatment resistant although I don't know how many drugs you have to fail to be declared treatment resistant.
That you have become resistant to the drug that you responded to previously gives evidence that something in the brain has changed since your initial exposure. It may be that physiological adaptations to the drug have occurred as a result of your exposure to it. We know that exposure to these drugs leads to changes in receptor sensitivities. Perhaps such changes in dynamics persist after drug discontinuation. I guess it is also possible that this treatment resistance would have occurred anyway as a result of the natural course of the illness. However, my own experience leads me to believe that drug exposure can indeed produce changes in therapeutic responsitivity. I became unresponsive to Nardil within two weeks of its being discontinued and subsequently restarted. Pulsing of antidepressants is probably a bad idea for some people.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:944856
URL: http://www.dr-bob.org/babble/20100425/msgs/945121.html